Anthracene and 1,8-napthalimide aminothiazole hybrids: Synthesis, Antimicrobial activity and Molecular Docking Studies

With our efforts to develop potent antimicrobial agents, a series of anthracene and 1,8-napthalimide aminothiazole analogues were synthesized characterized by using fundamental spectral analysis. All the hybrids screened for their anti-microbial activities against bacterial strains E. coli, B. subtillis, S. aureus, fungal A. niger C. albicans. Among compounds investigated, 4c, 4d, 6c exhibited most activity. Fluconazole Norfloxacin used as standard drugs antifungal antibacterial The molecular docking investigation revealed that 4d displayed lowest binding energy values within promoter regions PDB ID (1JIJ, 4WMZ). in vitro activity results are well corroborated with results.